Ultrapure water (UPW) is a critical component in capsule production, whose purity defines the final product quality. It is used in capsule manufacturing for gelatin/HPMC (Hydroxypropyl Methylcellulose) preparation, capsule washing, equipment cleaning (CIP), final rinsing, and controlled humidification. Even minor impurities could impact product quality and compliance. As the client relied on well water as the primary source, they sought a robust and consistent ultrapure water (UPW) solution to ensure reliable, consistent, and compliant production.
Challenges
A leading pharmaceutical company needed to treat well water for capsule production, which had high conductivity, organic load, and microbial presence, each posing a direct risk to process stability and product quality. The variability of well water further complicated operations, as fluctuations in ionic and organic content made it difficult to achieve consistent downstream performance.
In addition, it required a solution which can control microbes without the use of chemicals, while reliably delivering 1 m3/hr of UPW without compromising on quality, compliance, or operational consistency. The client sought a solution that could easily integrate with the existing conventional pre-treatment system to ensure reliable capsule manufacturing.
